Abstract 17807: Improvement in Regional Myocardial Function Assessed by Strain Rate Imaging in Patients who had Coronary Artery Disease but Normal Wall Motion Undergoing Percutaneous Coronary Intervention
Background : In patients with normal left ventricular(LV) wall motion but angiographically significant coronary artery stenosis, we evaluate the regional myocardial dysfunction and compare strain and strain rate between before percutaneous coronary intervention (PCI) and 6 months follow-up using speckle tracking imaging.
Methods : Standard echocardiography and speckle tracking imaging were performed in 22 patients with stable angina pectoris with angiographically significant coronary artery stenosis (> 70% narrowing in the major coronary artery) but normal wall motion before PCI and after 6 months later. We measured left ventricular (LV) longitudinal strain and strain rate in global and 396 regional segments (147 ischemic and 249 nonischemic).
Results : All analyzed strain data were decreased in the ischemic segments than nonischemic segments(10.9±5.0 vs 23.1±6.3, p<0.01). PCI caused a significant increase in peak systolic strain and peak early diastolic strain rate but not peak systolic strain rate and peak late diastolic strain rate in the ischemic segments after 6 months follow-up(shown in table).
Conclusion : In patients with significant coronary artery stenosis but normal LV function assessed by routine gray scale 2D echocardiogram, SR imaging demonstrated the regional LV dysfunction in the ischemic segments and improvement in regional LV dysfunction after PCI. Therefore, SR imaging is a sensitive and accurate tool in myocardial dysfunction assessment Values given are mean ± standard deviation. Values of strain was percent (%) and values of strain rate was 1/sec. *: p<0.01, p value was analyzed between before PCI and 6month later
- © 2012 by American Heart Association, Inc.