Abstract 17642: Brachial and Digital Measures of Endothelial Function and Inflammatory Markers in the Framingham Heart Study
Introduction: Endothelial dysfunction and systemic inflammation are precursors of atherosclerosis and contribute to the development of cardiovascular disease. The relation of systemic inflammation with vascular function measures in the digital and brachial arteries remains incompletely defined.
Methods and Results: In participants from the Framingham Offspring, Third Generation, and minority Omni Cohort 1, we evaluated brachial (flow-mediated dilation (FMD) and hyperemic flow velocity, n=7,190, age 49±14 years, 53% women) and digital (peripheral artery tonometry (PAT), n=4,395, age 55±16 years, 51% women) endothelial function. Concurrently, we assessed 10 biomarkers representing multiple inflammatory pathways: C-reactive protein, intercellular-adhesion molecule-1 (ICAM-1), interleukin-6, urinary isoprostanes, lipoprotein-associated phospholipase A2 (LpPLA2) activity and mass, monocyte chemoattractant protein-1, osteoprotegerin, P-selectin, and tumor necrosis factor receptor II (TNF R2). In age- and sex-adjusted models, multiple inflammatory biomarkers were associated with lower FMD (r=-0.03 for interleukin-6, p=0.007, to r=-0.03 for P-selectin, p=0.017), lower hyperemic flow (r=-0.04 for TNFR2, p=0.002 to r=0.03 for isoprostanes, p=0.03) or lower PAT ratio (r=-0.04 for isoprostanes, p=0.01 to r=-0.10 for CRP, p<0.0001). After adjusting for standard cardiovascular risk factors, none of the biomarkers were statistically associated with FMD, hyperemic flow, or PAT ratio.
Conclusion: In our large community-based study, we observed modest associations of inflammatory biomarkers with brachial and digital vascular function that were attenuated after adjustment for traditional cardiovascular risk factors. Our findings indicate that the relation of systemic inflammation with both conduit and microvascular endothelial dysfunction is largely mediated by co-existing risk factors.
- © 2012 by American Heart Association, Inc.