Abstract 176: Application of New Massive Transfusion Protocol Does Reduce Mortality from Hemorrhagic Shock in Trauma Patients
Background: Hemorrhage is most common cause of preventable death in trauma patients. There were many papers about application of the rule 1:1:1 (packed res blood cells : fresh frozen plasma : platelets) during resuscitation of trauma patients. We implemented this new massive transfusion protocol in our Trauma center during the year 2009 with mandatory application in the year 2010. The aim of our study was to search impact of new designed massive transfusion protocol on the mortality of trauma patients.
Methods: We retrospectively analyzed database of our Trauma Center Level I. We included all patients transported from the rural area from the scene of injury directly to the Trauma Center Level I with ISS>15 during the years 2008 and 2011. Patients with head AIS>3 were excluded. Statistical analysis was performed by unpaired t-test, Mann-Whitney test and Fisher exact test.
Results: There were 94 (y. 2008) and 104 (y. 2011) patients respectively. Both groups were comparable. We found significant decreasing of mortality because hemorrhage from 8 to 4 patients respectively (p=0.049). Also there was significant decreasing of the ratio of death because hemorrhage from 80% to 57% (p=0.027). Conclusions: We conclude that transfusion protocol with the rule 1:1:1 is very effective in the treatment of multiple trauma patients. Their application led to significant decreasing of death of trauma patients from the rural area of Trauma Center Level I in the Czech Republic.
- © 2012 by American Heart Association, Inc.