Abstract 17427: Coronary Endothelial Dysfunction In Patients with Early Coronary Artery Disease is Associated with the Increase in Lipid Core Plaque: Near-Infrared Spectroscopy Study
Although endothelial dysfunction plays a key role in the development of atherosclerosis and has been considered an early marker for atherosclerosis, only a few reports have demonstrated an association between endothelial dysfunction and atherosclerosis in the patients with early coronary artery disease. Therefore, the present study used near-infrared spectroscopy (NIRS) to investigate that coronary endothelial dysfunction is associated with the lipid core plaque (LCP) in the patients with early coronary artery disease.
Methods: A total of 32 chest pain patients who have diameter stenosis <30% were enrolled. All patients received coronary endothelial function test using intracoronary acetylcholine infusion and NIRS in the proximal left anterior descending artery. Lipid core burden index (LCBI), LCBI/L (LCBI divided by the length of scanned artery), maxLCBI4mm (maximum value of LCBI for any of the 4-mm segment) and block chemogram (yellow: probability of LCP presence>0.97, tan: 0.84≤p≤0.98, orange: 0.57≤p≤0.84, red: p<0.57) were measured.
Results: There was a significant correlation between LCBI (r=-0.502 p=0.0134), LCBI/L (r=-0.523, p=0.0157) and maxLCBI4mm (r=0.486, p=0.0123) and percent change of coronary artery diameter in response to acetylcholine. However there was no significant correlation between LCBI (r=-0.167, p=0.709), LCBI/L (r=-0.192, p=0.642) and maxLCBI4mm (r=-0.143, p=0.738) and percent change of coronary blood flow. Percentage of yellow, tan and orange color blocks in the patients with epicardial endothelial dysfunction was significantly higher than in those with normal epicardial endothelial function (4.8% vs. 9.6% p=0.004).
Conclusions: The patients with early coronary artery disease had greater LCP burden and larger LCP as they have more severe epicardial endothelial dysfunction. These results are consistent with the hypothesis that endothelial dysfunction may play an important role in the pathogenesis of atherosclerosis.
- © 2012 by American Heart Association, Inc.