Abstract 17348: Prevalence and Relation of Left Ventricular Diastolic Dysfunction and Hypertrophy in a Community-Based Population
Background: Left ventricular (LV) hypertrophy is considered as a critical factor of diastolic dysfunction, although various factors for the causes of the LV diastolic dysfunction other than LV hypertrophy exist. Nevertheless, the prevalence of LV diastolic dysfunction in subjects with LV hypertrophy has not been investigated. We aimed to examine the prevalence of LV hypertrophy and the association between the risk factors and LV hypertrophy in a community-based population.
Methods: We studied 1401 community-dwelling subjects without obvious heart diseases (mean age, 63±11 years; 548 men, 853 women) who participated in annual health checkups in a rural Japanese community, Arita-cho. The population was divided into 5 groups referring to LV mass index. LV diastolic dysfunction was determined with the waves of transmitral flow and mitral annular velocity. LV hypertrophy was defined as the top quintile of LV mass index.
Results: The prevalence of LV diastolic dysfunction was increased along with increases in LV mass. Interestingly, even in the top quintile, 37% of the subjects had normal diastolic function, whereas 28% of the subjects in the lowest quintile had diastolic dysfunction. In multivariate logistic analyses for LV diastolic dysfunction, age (OR 2.08 (95% CI 1.67-2.60) as the rise of 10 years), body mass index (OR 1.06 (1.01-1.12)), LV mass index (OR 1.01(95% CI 1.00-1.02)), brachial-ankle pulse wave velocity (OR 1.13 (95% CI 1.06-1.21)), and the presence of hypertension (OR 1.43 (95% CI 1.03-1.99)) were independent predictors of LV diastolic dysfunction.
Conclusion: LV diastolic dysfunction was observed in about 40% of the community-based population without the obvious symptoms of heart failure. LV hypertrophy was linked to LV dysfunction, however, The subjects of LV dysfunction without LV hypertrophy were also observed, since LV dysfunction was independently linked to high age, obesity, arterial stiffness and hypertension other than LV hypertrophy.
- © 2012 by American Heart Association, Inc.