Abstract 17298: Blood Pressure Variation During High Salt Intake, but Not Low Salt Intake, Was Associated with Cardiovascular Events in Patients with Hypertension
Introduction: Increasing body of evidence suggests that blood pressure variation (BPV) is a strong predictor of future cardiovascular (CV) events in patients with hypertension. However the effect of high salt intake, BPV and prognosis of hypertension are not known.
Method: In the present study, we analyzed the prevalence of CV events in patients with hypertension (n=47) whose systolic BPV were determined under three different conditions of salt intake; regular (10g/day NaCl diet), low (3g), and high (20g) salt. These evaluations of BPV were performed after admission in Hiroshima University Hospital between 1988 and 1992. Standard deviation (SD) of systolic blood pressures (SBP) measured every hour through 0600 to 2300 was determined as BPV under the three conditions of regular diet protocols. The clinical course was followed up for 22±5.8 years in average after determining BPV.
Results: SD of SBP in regular salt (12.5±0.7) and high salt diet (12.8±0.7) periods were significantly (p<0.03) larger than that in low salt diet period (10.2±0.7). ROC analyses revealed that SD of SBP during regular salt intake (AUC= 0.66, 95%CI: 0.53-0.74) and high salt intake (AUC=0.72, 95%CI: 0.58-0.79), but not that of low salt intake, was significantly associated with CV events.
Conclusion: These results suggest that high salt intake enhances BPV, which leads to end organ damage and CV diseases.
- © 2012 by American Heart Association, Inc.