Abstract 17281: Plasma levels of n-3 Polyunsaturated Fatty Acids, Inflammatory Cytokines, and Risk of Hospitalization in Patients with Non-Ischemic Cardiomyopathy
Purpose: In patients (pts) with left ventricular (LV) dysfunction, levels of inflammatory cytokines are increased and are associated with worse prognosis. N-3 polyunsaturated fatty acids (PUFAs) exert multiple anti-inflammatory actions. We explored, in patients with non-ischemic cardiomyopathy (NICM), the associations between levels of n-3 PUFA and levels of inflammatory cytokines and the risk of hospitalization (hosp).
Methods: Baseline levels of docosahexaenoic (DHA) and eicosapentaenoic acid (EPA), and of the cytokines TNF-α, IL-6, and IL-1 were measured in 133 pts with NICM who participated in a randomized, placebo-controlled trial designed to test the effects of one-year supplementation with 2 g of n-3 PUFAs on LV systolic function. Outcomes included all-cause Hosp, cardiovascular (CV) hosp and hosp for heart failure (HF), We used linear regression models to study the association between levels of DHA, EPA and of the TNF-α, IL-6, and IL-1. For each hosp outcome, the response variable was treated as binary. Logistic regression models were used for each of the hosp outcomes.
Results: For each unit increase in DHA level, TNF-α decreased by 15.25 units (p<0.0001), IL-6 by 1.68 units (p=0.22), and IL-1 by 138.11 units (p=0.0014), respectively. For each unit increase in the EPA level, TNFα decreased by 6.08 units (p=0.25), IL-6 increased by 0.16 units (p=0.95), and IL-1 decreased by 64.70 units (p=0.41), respectively. The associations between cytokine levels and hosp outcomes are reported in Table. With adjustment for TNF-α, for each one-unit increase in DHA level, the odds ratio of all-cause hosp was 0.043 (p<0.0001), of HF hosp was 0.0051 (p<0.001), and of CV hosp was 0.091 (p=0.01), respectively.
Conclusions: In pts with NICM, higher levels of DHA are inversely associated with levels of TNF-α and IL-1; levels of TNF-α and IL-6 are associated with increased risk of hosp; and higher DHA levels are associated with lower probability of hosp after adjusting for TNF-α.
- © 2012 by American Heart Association, Inc.