Abstract 17278: Planned Invasive compared to Conservative Treatment in Patients with Negative High Sensitivity Troponin at Randomization in Patients with Non-ST-Elevation Acute Coronary Syndrome - A Platelet Inhibition and Patient Outcomes (PLATO) Trial Blood-Core Subgroup Analysis
Background. In patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) current guidelines recommend an early invasive treatment at an elevation of troponin. We evaluated outcomes with at randomization declared planned invasive versus non-invasive treatment in the NSTE-ACS cohort in the PLATO trial.
Methods. In the PLATO trial 7.3 % (n=1,361) of all patients presented with NSTE-ACS and high sensitivity troponin T (hs-cTnT) <99th percentile (<14 ng/L) and were randomized to ticagrelor or clopidogrel. Cox proportional hazard models with multivariable adjustment for randomized treatment and baseline characteristics were performed.
Conclusions. In patients with NSTE-ACS and normal hs-cTnT planned early invasive treatment is associated with an increase in early procedure related MI and bleedings but no differences in long-term spontaneous MI, non-procedure related bleedings or mortality.
- © 2012 by American Heart Association, Inc.