Abstract 17195: Association between Reading-to-Reading Blood Pressure Variability and the Severity of Obstructive Sleep Apnea in Patients with Hypertension
Background: Obstructive sleep apnea is one of the important causes of hypertension and a risk factor of cardiovascular disease. Recent studies have reported that increased reading-to-reading blood pressure variability is an independent risk factor of adverse cardiovascular events and mortality after adjusting for blood pressure. However, whether or not the severity of obstructive sleep apnea influences the degree of blood pressure variability has not been investigated. Thus, we investigated whether the severity of sleep-disordered breathing is associated with blood pressure variability.
Methods and Results: We retrospectively enrolled 88 patients with hypertension who had undergone both 24 hour ambulatory blood pressure monitoring (A&D Medical, TM-2430) and portable polysomnography (Embla Systems, Embletta® X100). As measures of reading-to-reading blood pressure variability we used the time interval-weighted standard deviation (SD) between consecutive readings (SD24), the average of day and nighttime SD weighted for the duration of the day and nighttime (SDdn), and the average real variability weighted for the time interval (ARV). The severity of obstructive sleep apnea was measured by apnea hypopnea index (AHI) and oxygen desaturation index (ODI). The mean of SD24, SDdn and ARV were not significantly different among the groups which were classified according to the level of AHI (∼5, 5∼15, 15∼30, 30∼). Univariate and Multivariate linear regression did not show significant association between AHI or ODI and SD24 or SDdn or ARV.
Conclusions: The results from this study did not demonstrate significant association between the indices of ambulatory blood pressure variability and the severity of sleep-disordered breathing.
- © 2012 by American Heart Association, Inc.