Abstract 17001: Long-Term Benefits of Vagal Nerve Stimulation Therapy in Heart Failure
Purpose and Background: Chronic Vagus Nerve Stimulation (CVNS) has been studied in a multicenter trial as a new therapeutic option for patients with chronic heart failure (CHF), with previously reported promising 6 month and 12 month results. The goal of the present study was to assess long-term effects of CVNS in an extension of the original study.
Methods: Stable NYHA II-IV class CHF subjects on optimized therapy (n=32, age 56±11 years) were implanted with the CardioFit system consisting of a pulse generator, a proprietary multipolar stimulation lead placed on the right cervical vagus and a right ventricular sensing lead. All echocardiographic data were independently reviewed by a blinded core lab. Longitudinal regression analysis was performed to assess the significance of the changes observed through 24 months of therapy.
Results: Extended follow-up evaluation (24 months) of therapy was performed and is available for 19 subjects; Holter recording analyses from 13 subjects; paired echocardiograms from 7 subjects. Median follow up is currently 33.5 months (range: 24-59 months). The presented data demonstrates persistent, long-term effect of CVNS as a novel modality for CHF. These results are similar to those observed at 6 and 12 months follow up.
Conclusions: The current data indicates that the favorable effects of CVNS therapy in patients with CHF are maintained long-term. These findings need to be confirmed in larger controlled clinical trials, which are underway.
- © 2012 by American Heart Association, Inc.