Abstract 16825: Increased Pericardial Adipose Tissue Volume is Associated with Adverse Left Ventricular Remodeling After Acute Myocardial Infarction
Background: Pericardial adipose tissue (PAT) has been shown to predict the prevalence and progression of coronary artery disease. However there are no data on the potential role of PAT on left ventricular remodeling in patients after acute myocardial infarction (AMI). Therefore, we measured PAT by serial cardiac MRI after AMI, and determined its relation to clinical outcome and cardiac function.
Methods: PAT volume was analyzed in 109 patients by serial MRI four-seven days after AMI as well as after 4-months.
Results: Initially, left ventricular ejection fraction (LVEF) was modestly reduced (48.9 ± 10.6 %) and PAT volume was 181±75 cm³. There was no correlation between PAT volume at baseline and initial LVEF, left ventricular end-diastolic volume (LVEDV) or left ventricular end-systolic volume (LVESV). At 4 months, LVEF significantly improved to 53.2 ± 12.7% and PAT volume remained essentially unchanged (168 ± 69 cm³) for the entire study cohort. However, an increase in PAT volume at 4 months was significantly (p=0.03) correlated with a decrease in LVEF and an increase in LVESV. In fact, patients with evidence of adverse LV remodeling as measured by increased LVESV at 4 months (n=47) had a significantly (p=0.002) greater PAT volume at 4 months compared to patients without adverse remodeling. Likewise, patients with adverse LV remodeling demonstrated a significant (p=0.04) increase in PAT volume within 4 months after AMI, whereas no significant change was observed in patients without adverse LV remodeling. There was no association between changes in PAT volume and body mass index as well as parameters of glucose - or lipid - metabolism (LDL, HDL and HbA1c).
Conclusion: Adverse left ventricular remodeling post-AMI is associated with a significant increase in pericardial adipose tissue volume, indicating that the adversely remodeling heart signals to the pericardial fat tissue.
- © 2012 by American Heart Association, Inc.