Abstract 16821: Common Atrial Fibrillation Susceptibility Alleles - Predictors for Atrial Fibrillation Recurrence after Catheter Ablation?
Background: Genome-wide association studies uncovered common alleles on chromosomes 1q21 (rs13376333), 4q25 (rs10033464 and rs2200733) and 16q22 (rs7193343) to confer risk for atrial fibrillation (AF). The aim of this study was to investigate the possibility of their predictive potential for AF recurrence after radiofrequency catheter ablation (RFCA).
Methods: We studied 499 consecutive patients (66.7 % males, mean age 58.6 +/- 10.2 years) with paroxysmal (62 %) or persistent (38 %) AF who underwent RFCA. Genotypes were determined using real-time polymerase chain reaction in combination with fluorescence resonance energy transfer. AF recurrence (> 30 sec) was detected using serial 7-day Holter ECG recordings immediately, as well as 3, 6 and 12 months after RFCA.
Results: Early AF recurrence (ERAF) within the first week after RFCA was observed in 35.9 % and late AF recurrence (LRAF) between 3 and 12 months in 28.9 %. Minor allele frequency was 35.2 % in rs13376333, 11.6 % in rs10033464, 28.2 % in rs2200733 and 21.9 % in rs7193343. Using a dominant genetic model variant carriers of rs13376333 (1q21) (OR 1.827, 95 % CI 1.238 - 2.695, p=0.002) and rs2200733 (4q25) (OR 1.841, 95 % CI 1.092 - 3.104, p=0.021) had a higher risk for ERAF. Rs7193343 (16q22) was associated with a lower risk for LRAF in a dominant genetic model (OR 0.643, 95 % CI 0.429 - 0.963, p=0.032). Other genetic data were not associated with recurrence.
Conclusions: Rs7193343 (16q22), rs2200733 (4q25) and rs13376333 (1q21) associate with AF recurrence after RFCA. Replication of these findings and further studies to evaluate the possibility of genotype-based individualized AF therapies are required.
- © 2012 by American Heart Association, Inc.