Abstract 168: A Novel Noninvasive and Simple Method for Assessment of Endothelial Function: Enclosed Zone Flow-Mediated Vasodilation Using an Oscillation Amplitude Measurement
Background: It is clinically important to estimate the degree of endothelial dysfunction. Several methods have been used to assess endothelial function in humans. Recently, we developed a new noninvasive method for measurement of vascular response to reactive hyperemia in the brachial artery, named enclosed zone flow-mediated vasodilation (ezFMD). The purpose of this study was to determine the validity of ezFMD for assessment of endothelial function.
Methods and Results: We measured ezFMD by a new device using an oscillometric method and conventional FMD using ultrasonography in 306 subjects, including patients with hypertension, dyslipidemia, and diabetes mellitus (218 men and 88 women, 30±16 yr). Univariate regression analysis revealed that ezFMD significantly correlated with age (r=-0.42, P<0.0001), body mass index (r=-0.13, P=0.028), systolic blood pressure (r=-0.15, P=0.009), diastolic blood pressure (r=-0.14, P=0.011), fasting glucose level (r=-0.27, P=0.006), smoking (r=-0.21, P=0.007) and baseline pulse wave amplitude (r=-0.51, P<0.0001). ezFMD significantly correlated with FMD measured by ultrasonography (r=0.34, P<0.0001). Multiple regression analysis revealed that age (P=0.002), body mass index (P=0.013), systolic blood pressure (P=0.009), smoking (P=0.004) and baseline pulse wave amplitude (P<0.001) were independent predictors of ezFMD.
Conclusions: These findings suggest that measurement of ezFMD, a novel noninvasive and simple method, may be useful for determination of vascular diameter response to reactive hyperemia. Since ezFMD is automatically measured by a device with an oscillometric method, measurement of ezFMD is more simple and less bias than is measurement of conventional FMD.
- © 2012 by American Heart Association, Inc.