Abstract 16467: Impact of Serum Eicosapentanoic Acid / Arachidonic Acid Ratio ( n-3/n-6 Polyunsaturated Fatty Acid Ratio ) on Post -Procedural Myocardial Infarction after Coronary Intervention
Background The serum eicosapentaenoic acid (EPA) / arachidonoic acid (AA) ratio has been associated with vulnerable coronary lesions and cardiovascular events. However, the association of serum EPA / AA ratio and post-procedural myocardial infarction (PMI) after percutaneous coronary intervention (PCI) is not clear. The aim of this study was to examine the relationship between serum EPA / AA ratio and PMI who underwent elective PCI.
Method Between June 2009 and December 2011, a total of 300 consecutive patients with stable angina who underwent elective PCI were enrolled. We evaluated serum EPA/AA ratio before PCI and Troponin T (TnT) at 12 - 24 hours after PCI. PMI was defined as an elevation of TnT level more than upper limit of normal (0.1pg/dl).
Result We divided the patients into two groups, PMI group (n = 101) and non-PMI group (n = 199). There was no statistical significance in the baseline characteristics between the two groups. EPA / AA ratio was significantly lower in the PMI group than in the non-PMI group (0.33±0.18 vs. 0.38±0.32 , P<0.0001). On the logistic regression analysis after adjustment of confounding factors, serum EPA / AA ratio independently associated with PMI (OR:0.16, 95%CI: 0.034 to 0.722, P<0.0001).
Conclusion The lower serum EPA / AA ratio was independently associated with PMI.
- © 2012 by American Heart Association, Inc.