Abstract 16297: The Relationship Between Albumin Excretion and Early Markers of Cardiovascular Disease Risk in Adolescents with Type-1 Diabetes: The AdDIT Study
Aim: To determine the relationship between albumin excretion and early markers of cardiovascular risk in adolescents with Type-1 diabetes (T1D).
Methods: Subjects (age: 10-16 years) recruited into the adolescent type-1 diabetes cardio renal intervention trial (AdDIT) from 33 centres in Australia, Canada and the UK underwent vascular phenotyping (Blood pressure (BP), carotid intima media thickness (cIMT), flow mediated dilatation (FMD), digital plethysmography (EndoPAT) and pulse wave velocity (PWV)) and had blood taken for cardiovascular biomarkers. Two sets of 3 early morning urine samples was used to define low, middle and upper tertile of ACR, after adjusting for age, gender and T1D duration.
Results: *P < 0.05, †P<0.001
Conclusions: Subjects with the highest albumin excretion had a higher PWV, were more likely to have abnormal DBP and showed evidence of hyperfiltration. In T1D adolescents, increased albumin excretion, even within the normal range, is a marker of early vascular damage. AdDIT will examine in a randomised control trial, whether intervention with statin ±ACE inhibitor will prevent progression and/or reverse these adverse vascular changes.
- © 2012 by American Heart Association, Inc.