Abstract 16058: Comparing Symptoms and Quality of Life in Women and Men with Atrial Fibrillation: Results from the Orbit-AF Registry
Background: Reducing symptoms and improving quality of life (QoL) are important treatment goals in atrial fibrillation (AF). Yet little is known about how patient-reported QoL differs between women and men with AF.
Methods: We analyzed patient characteristics, treatment, symptoms, and Atrial Fibrillation Effect on QualiTy-of-life (AFEQT) scores bewteen males and females in the ORBIT AF registry QoL substudy. Linear regression was used to evaluate the association of sex and AFEQT scores after log transformation.
Results: We evaluated 1145 men and 860 women (43%) with AF from 100 US practices participating in ORBIT. The mean population age was 74 ± 11, the mean CHADS2 score was 2.2±1.3. Despite a higher LVEF (58±11 vs 53±12, p<.0001) and more sinus rhythm at enrollment (37 vs 30%, p=0.005), women had lower AFEQT scores compared with men: 75±21 vs. 79±19 (p<.0001). Women also had more reported symptoms than men (Table). There were no sex differences in the use of rhythm control (30 vs 30%, p=0.9428) nor oral anticoagulation (78 vs 81%, p=0.0957). After adjustment for baseline characteristics, female sex was associated with 52% (95% CI 38-68%) lower AFEQT QoL scores (p<0.0001).
Conclusions: Women with AF have worse QoL than men. Future studies should focus on how treatment and interventions specifically impact AF-related QoL in women and men.
- © 2012 by American Heart Association, Inc.