Abstract 15962: Sensitivity and Specificity of High Sensitive Cardiac Troponin T for Predicting Stable Ischemic Heart Disease and its Severity in 4608 Japanese High-Risk Participants

Abstract

Introduction Detectable levels of cardiac troponin T (cTnT) have become increasingly more sensitive.Recently, the highly sensitive assay for cTnT (hs-cTnT) has been developed. However,it is unclear whether its levels were useful in Japanese, because Japanese population differ the event rate of ischemic heart disease (IHD) compared with Western population. We investigated whether there is an association between the level of hs-cTnT and angiographic severity of coronary artery disease and whether this association is independent of conventional risk factors and other biomarkers. Design,Method, and Patients Patients with stable and asymptomatic IHD performed percutaneous coronary intervention (CAD group:n=1359, age 64.3±9.8y.o., male 83.7%) and outpatients with one or more conventional coronary risk factors without past history of IHD and heart failure (Control group: n=3249, age 64.7±10.7y.o., male 43.9%) were divided into quintiles of hs-cTnT levels. <Figure1>Results The odds ratio of incidence of IHD increased from the lowest hs-cTnT quintile to the highest.<Figure 1>. From ROC analysis, sensitibity of hs-cTnT to determine CAD patients was 82.9% and its specificity was 62.6% (cut off value; hsTnT>0.0045ng/ml). When we identify cut-off at 0.003ng/ml (undetectable limit) and 0.015ng/ml (standard detection limit), their sensitivity and specificity of IHD were 90.4%, 49.5% and 28.5%, 93.6%, respectively. There is a close association between hs-cTnT level and severerity of coronary arteries confirmed by the number of narrows coronary arteries. Conclusion Hs-cTnT is a useful biomarker for predicting IHD in Japanese patients who were at high risk for cardiovascular disease high risk Japanese as well as Western population, and it was associated with the severity of coronary arteries.CAD.