Abstract 15682: Impact of Hypertriglyceridemia on Coronary Artery Saphenous Vein Bypass Graft Occlusion
Introduction: Saphenous vein graft (SVG) occlusion is frequently encountered in coronary angiography. Maintaining a low-density lipoprotein (LDL) level <70 mg/dL in patients post-coronary artery bypass graft (CABG) surgery is critical. Data on the effect of triglyceride (TRG) level on SVG atherosclerosis is scant. Our objective was to test the interaction of LDL and TRG levels on SVG occlusion.
Methods: We retrospectively studied 1,000 consecutive patients (mean age 66 years, 66% men) who underwent CABG surgery from January 2000 to August 2004 for the presence of SVG occlusion on coronary angiogram. Follow-up data were available through October 2011. Fasting lipid profile measurements were recorded. Wilcoxon rank-sum and chi-square/Fisher's exact tests were used to analyze data.
Results: Of the 1,000 patients, 752 maintained LDL level <70 mg/dL and/or TRG level ≤150 mg/dL. When patients achieved optimal level of LDL (<70 mg/dL), SVG occlusion was significantly higher in those who had TRG level >150 mg/dL as compared with those with TRG level ≤150 mg/dL (Table). However, when patients achieved TRG level ≤150 mg/dL, there was no difference in occlusion rate regardless of LDL level. Multivariate analysis demonstrated SVG occlusion was more strongly associated with TRG level (odds ratio, 2.2; 95% confidence interval [CI], 1.7-3.1; p<0.001), than with LDL level (odds ratio, 1.1; 95% CI, 0.8-1.6; p=0.661).
Conclusion: Triglyceride level, not LDL level, is the main dyslipidemic factor of coronary artery saphenous vein bypass graft occlusion.
- © 2012 by American Heart Association, Inc.