Abstract 15675: Increased Osteoprotogerin and Osteopontin Serum Levels are Associated with Multivessel Coronary Artery Disease
Background: Coronary artery disease (CAD) is one of the most important manifestations of atherosclerosis. Osteoprotogerin (OPG) and osteopontin (OPN) has recently emerged as key factor in both vascular remodeling and development of atherosclerosis. The study was designed to evaluate the association of serum concentration of OPG and OPN with multivessel CAD.
Methods: The study population consisted of 409 subjects undergoing diagnostic coronary angiography for suspected CAD. Angiography categorized subjects in: 280 patients with single-vessel (1VD) or multivessel (2VD, or 3VD) CAD (mean aged 61±11years), and in: 129 healthy subjects, as control group (CL), (mean aged 60±12 years). Serum OPG and OPN levels were measured, using ELISA.
Results: CAD patients had significantly higher levels of OPG (3.91±1.87 pmol/l vs. 2.88± 2.17 pmol/l, p<0.001) and logOPN (1.81±0.18 ng/ml vs. 1.71±0.24 ng/ml, p<0.001). Analysis of variance revealed that OPG (CL:2.87±2.17 vs.1VD:3.75±1.76 vs. 2VD:3.41±1.68 vs. 3VD:4.48±2.15 pmol/l, p<0.001) and logOPN (CL:1.72±0.24 vs. 1VD:1.82±0.18 vs. 2VD:1.76±0.18 vs. 3VD: 1.88±0.22 ng/ml, p<0.001) levels were affected by the extend of CAD. The association of OPG levels with multi vessel CAD was also confirmed by ROC curve analysis, where OPG levels have sufficient discriminating ability to detect three vessels CAD in patients suspected for CAD before undergoing diagnostic coronary angiography (AUC=0.644, 95% CI: 0.564, 0.723, p=0.001), while the best discriminate value of OPG to detect 3 vessels disease was assessed at 4.46 pmol/l with a sensitivity of 57% and a specificity of 70%.
Conclusion: Our findings indicate that increased OPG and OPN levels are associated with multivessel CAD and increased OPG levels can predict multivessel CAD.
- © 2012 by American Heart Association, Inc.