Abstract 15605: Biomarkers Associated with Progression of Arterial Stiffness
Objectives: Arterial stiffness increases with age and is associated with adverse cardiovascular events. We sought to identify circulating biomarkers associated with progression of arterial stiffness.
Methods: The cohort was comprised of 533 non-Hispanic White participants belonging to hypertensive sibships from the GENOA study. Arterial tonometry was performed at baseline on radial, carotid and femoral arteries, then repeated after a mean follow-up of 8.5±0.9 years to obtain central pulse pressure (CPP) and carotid-femoral pulse wave velocity (cfPWV). Z-scores for CPP and cfPWV were calculated and compared at the two time points to estimate progression. Biomarkers that were previously identified to be associated with pulse pressure in non-Hispanic Whites (N-terminal pro brain natriuretic peptide [NT-proBNP], mid-regional pro atrial natriuretic peptide [MR-proANP], osteoprotegerin and fibrinogen) were used in the present analyses. Multivariable linear regression analyses were performed to assess the associations of the biomarkers with progression of cfPWV and CPP, after adjustment for age, sex, follow-up time, body mass index, hypertension, diabetes, smoking, estimated glomerular filtration rate, and baseline CPP or cfPWV.
Results: Mean±SD age at baseline was 58±9 years, 57% were women, 78% were hypertensive and 21% were diabetic. During follow-up, mean CPP increased from 43±13 mmHg to 68±21 mmHg and mean aPWV increased from 9.3±2.5 m/s to 11.4±3.7 m/s. Multivariable regression results are summarized in the Table. Higher NT-pro BNP and MR-proANP levels at baseline were significantly associated with greater progression of CPP, while higher baseline fibrinogen was associated with greater progression of cfPWV.
Conclusions: Markers of inflammation and hemodynamic stress were significantly associated with progression of central arterial stiffening.
- © 2012 by American Heart Association, Inc.