Abstract 15518: Restenosis Pattern of Drug-Eluting Stent: Impact of Stent Type
Background: Differences in restenosis pattern and timing between bare-metal stent and drug-eluting stent (DES) have been reported. However, little is known about the effect of the type of DES on restenosis pattern and timing.
Methods: From November 2002 to August 2010, 6676 consecutive patients were treated with sirolimus-eluting stent (SES: 6321 lesions), paclitaxel-eluting stent (PES: 1520 lesions), zotarolimus-eluting stent (ZES: 599 lesions), everolimus-eluting stent (EES: 924 lesions), and biolimus-eluting stent (BES: 288 lesions), and underwent midterm follow-up coronary angiography (f/u CAG) at 8 months after implantation. Of these, patients without restenosis underwent late f/u CAG at 12 months after midterm f/u. We defined early restenosis as restenosis at midterm f/u and late restenosis as restenosis at late f/u without early restenosis. Restenosis patterns were classified into two groups according to Mehran classification: focal (pattern I) and diffuse (pattern II, III, IV).
Results: At midterm f/u, the focal pattern was dominant in SES, EES, and BES, whereas the rates of focal and diffuse patterns were similar in PES and ZES. At late f/u, the similar trend of restenosis pattern was seen in SES, ZES, EES, and BES. However, the rate of restenosis pattern was significantly different in PES. Data are shown in the table.
Conclusion: Restenosis pattern at midterm f/u and late f/u depends on the type of DES. Only the restenosis pattern in PES can change between midterm f/u and late f/u. These results suggest that the mechanism of restenosis depends on the type of DES.
- © 2012 by American Heart Association, Inc.