Abstract 15460: Real Time Combined Optical Coherence Tomography and Intravascular Ultrasound Catheter Characterizes Atherosclerosis in-vivo Porcine Model
Introduction The major cause of cardiovascular death in acute coronary syndrome is due to less obtrusive vulnerable thin cap fibroatheromas (TCFA) that rupture suddenly. Vulnerable plaques cannot be seen by traditional angiography, as most of these occurrences have a length scale of 2∼150 microns. It is essential to develop a real time high resolution imaging technology that can resolve vascular tissue elements at such scales. The combination of Optical Coherence Tomography (OCT) and IVUS (intravascular ultrasound) in a single catheter provides the ability for such resolution, and provides for accurate assessment of TCFA’s.
Hypothesis We assessed the hypothesis that OCT and IVUS can be combined in a single catheter and used to obtain simultaneous real-time images with standard catheterization techniques in a porcine model.
Methods Yorkshire swine were anesthetized. Via femoral artery access, a coronary catheter was then used to engage the coronary system. A 0.014-inch guidewire was advanced into the coronary artery under fluoroscopic guidance over which the imaging catheter was advanced. Simultaneous co-registration of IVUS/OCT images using this single bimodal in vivo imaging catheter were obtained.
Results Imaging was performed in 4 animals. Representative OCT and IVUS images are demonstrated in Figure 1. OCT images demonstrate improved resolution, while IVUS images show increased depth of penetration. No adverse events occurred during evaluation with the device.
Conclusion To our knowledge, this is the first combined OCT-IVUS catheter successfully used in-vivo in a porcine model. In conclusion, the combined use of OCT and IVUS is an effective approach for evaluating atherosclerosis and warrants further evaluation and translation to clinical applications.
- © 2012 by American Heart Association, Inc.