Abstract 15437: Aortic Root Dimensions in Healthy Subjects: Clinical and Echocardiographic Correlates
Aim: To report the full range of aortic root diameters in healthy subjects and to investigate clinical and echocardiographic correlates.
Methods: 1236 healthy subjects [791 males, mean age 36.42± 13.96 vs. 445 females, mean age 36.97± 14.98 years (p=0.5), from 16 to 90 years] underwent a comphrensive transthoracic echocardiographic Doppler study. The end-diastolic aortic diameters were measured at 4 locations: (1) the aortic annulus, (2) the sinuses of Valsalva, (3) the sinotubular junction, and (4) the maximum diameter of the proximal ascending aorta.
Results: The aortic measurements were significantly higher in men than women at the annulus and sinus of Valsalva level, while at the supraortic ridge and ascending aorta level the diameters were similar. When the diameters were indexed by BSA the values were significantly higher in the female group but for the sinus of Valsava. The ratios of sinus of Valsalva and supraortic ridge to anular diameters were not different in the two groups (1.3± 0.12 vs 1.38± 0.10, p= 0.1 and 1.25± 0.1 vs 1.26± 0.08, p=0.6 in men and women respectively). Stepwise multiple linear regression analysis highlights age, left ventricular stroke volume (LV-SV), systemic blood pressures (BP) and E/A ratio as the most constant independent determinants of the aortic dimensions in males. In females independent variables were LV-SV and E/A ratio.
Conclusion: In a large group of healthy subjects with a wide age range, the aortic diameters indexed by BSA were higher in females than males. Distinct clinical and echocardiographic parameters should be taken into account when evaluating aortic root dimensions in females vs males
- © 2012 by American Heart Association, Inc.