Abstract 15198: Relationship Between Plasma Pentraxin 3 and Composition of Coronary Atherosclerotic Plaques Assessed by iMap-Intravascular Ultrasound
Background: Pentraxin 3 (PTX3) is a novel biomarker that is specific to localized vascular inflammation. However, whether plasma PTX3 reflects coronary plaque characteristics remains unclear. This study investigates whether the plasma PTX3 level is associated with the composition of coronary plaque as assessed by iMap-intravascular ultrasound (iMap-IVUS), a novel imaging system for tissue characterization.
Methods: We visualized coronary culprit plaques before percutaneous coronary intervention (PCI) in 41 and 3 patients with stable and unstable angina pectoris, respectively, using conventional IVUS and iMap-IVUS. The IVUS parameters were calculated at sites of minimal lumen areas. Plaque characteristics identified by iMap-IVUS were classified into fibrotic, lipidic, necrotic, and calcified components, and they are described herein as the absolute amount and ratio (%) of each area (FA, LA, NA, and CA, respectively). Plasma PTX3 was measured before PCI and a high-PTX3 was defined as plasma PTX3 level > 2.52 ng/mL of median value.
Results: Compared with the group without high-PTX3, the group with high-PTX3 had significantly greater vessel (15.9 ± 5.6 vs. 12.0 ± 5.9 mm2, p = 0.033) and plaque (13.5 ± 5.5 vs. 9.8 ± 5.5 mm2, p = 0.030) areas, larger absolute LA (1.78 ± 1.07 vs. 0.90 ± 0.53 mm2, p = 0.001) and NA (6.04 ± 3.23 vs. 3.19 ± 3.09 mm2, p = 0.005), higher %LA (12.1 ± 5.1 vs. 9.4 ± 2.3 %, p = 0.025) and %NA (41.0 ± 12.8 vs. 32.7 ± 16.3%, p = 0.005), and lower %FA (44.6 ± 13.5 vs. 55.7 ± 17.3%, p = 0.022). The absolute CA and %CA values did not significantly differ between the groups. The PTX3 level correlated positively with vessel (r = 0.35, p = 0.020), plaque (r = 0.36, p = 0.018) areas, absolute LA (r = 0.42, p = 0.004), absolute NA (r = 0.42, p = 0.005), %LA (r = 0.33, p = 0.030 and %NA (r = 0.35, p = 0.020), and inversely with %FA (r = -0.38, p = 0.011). Multivariate logistic regression analysis showed a significant association between a high-PTX3 and a larger absolute LA (odds ratio, 5.16; 95% confidence interval, 1.44 to 18.5; p = 0.012).
Conclusions: Coronary lesions in patients with a higher plasma PTX3 levels were associated with greater LA, NA, and smaller FA as assessed by iMap-IVUS. These findings suggest that plasma PTX3 could serve as a useful marker of plaque vulnerability.
- © 2012 by American Heart Association, Inc.