Abstract 15184: Diabetes Has a Strong Effect on the Progression of Atherosclerosis Independent of Metabolic Syndrome
Introduction: Metabolic syndrome (MS) and diabetes are important risk factors for atherosclerotic cardiovascular disease.
Hypothesis: We assessed the hypothesis that the effect of MS to the progression of atherosclerosis is different according to the presence of diabetes.
Methods: The measurement of brachial-ankle pulse wave velocity (baPWV) and carotid intima-media thickness (CIMT) were performed in 1639 adults (61±8 years, 66% men) who participated in community based cohort study as part of the healthcare program.
Results: Our 1639 participants were composed of 1382 (84.3%) non-diabetic and 257 (15.7%) diabetic patients. Patients with MS were 354 (25.6%) and 163 (63.4%) in both non-diabetics and diabetics, respectively. Diabetic patients had significantly higher values of both baPWV and CIMT compared with non-diabetic patients (P < 0.001, respectively). Patients with MS had significantly higher value of both baPWV and CIMT than those without MS in only non-diabetic individuals (P<0.001, respectively). The number of MS components was significantly correlated with both baPWV and CIMT in only non-diabetic patients (baPWV: r=0.250, P<0.001; CIMT: r=0.168, P<0.001). Multiple regression analysis showed diabetes and MS to be associated with both baPWV and CIMT in all subjects (P<0.001, respectively). According to diabetes status, MS was significantly associated with both baPWV and CIMT in only non-diabetic patients (baPWV: P<0.001, CIMT: P=0.002).
Conclusion: In conclusion, MS is significantly associated with the progression of atherosclerosis in only non-diabetic individuals, and diabetes has a strong influence on the atherosclerosis independent of MS.
- © 2012 by American Heart Association, Inc.