Abstract 15136: CHADS2 Score in the Prediction of Developing Dementia in Patients with Atrial Fibrillation: a Nationwide Population-Based Study
Background: Atrial fibrillation (AF) is associated with an increased risk of dementia. However, limited data are available on the predictors of dementia in patients with AF. This study aimed to evaluate whether CHADS2 score is useful for risk stratification of dementia development.
Hypothesis: Higher CHADS2 score is associated with an increased risk of dementia in patients with AF.
Methods: A universal national health insurance (NHI) program has been implemented in Taiwan since 1995. We used system sampling database from 2000 to 2009 with a total of 2,000,000 subjects. By using ambulatory and inpatient claim data, we included subjects with AF and were above 20 years old.
Results: Overall, 15,787 patients were identified, of whom 1470 (9.31%) had developed dementia. Kaplan-Meier analysis revealed a tendency of higher CHADS2 score toward dementia development (Figure 1; log rank test, p < 0.001). After multivariate Cox model adjustment for patients’ gender and selected comorbidities, hazard ratio of each increment of the CHADS2 scores to predict was 1.303 (95% con[[Unable to Display Character: ﬁ]]dence interval [CI]: 1.258 to 1.351, p<0.001).
Conclusions: The CHADS2 score is a useful predictor of dementia in patients with AF.
- © 2012 by American Heart Association, Inc.