Abstract 15027: Left Ventricular Mass is Associated with Orthostatic Leg Blood Pressure in Normotensive Subjects
Changing from supine to orthostatic posture leads to substantial increments in leg blood pressure (BP) levels, which could ultimately influence the hemodynamic burden imposed to the heart. This study investigated the relationship between brachial and leg BP and left cardiac chambers structure and further assessed the role of body posture changes in this regard.
Methods: One hundred thirty normotensive, non-diabetic, non-smoking, normolipemic subjects (59% women) were evaluated by clinical history, anthropometry, analysis of metabolic parameters, echocardiography, and had their BP measured in the arm and calf in supine and orthostatic positions.
Results: Changing from supine to standing substantially increased BP levels in the legs (p<0.001). Significant correlation coefficients between leg orthostatic BP measurements and cardiac structure were detected, especially between pulse pressure and left ventricular (LV) wall thickness (r=0.38; p<0.001), pulse pressure and LV mass (r=0.37; p<0.001), and systolic BP and left atrial size (r=0.35; p<0.001). Stepwise regression analysis adjusted for brachial BP, anthropometric and metabolic variables confirmed that leg orthostatic pulse pressure was independently related to LV wall thickness (p=0.02) and LV mass (p=0.03). Moreover, leg orthostatic systolic BP was associated with left atrial dimension even after adding LV mass to the statistical model (p=0.02). At last, triglycerides levels were the variable showing the most significant relationship with leg orthostatic pulse pressure and systolic BP. Conversely, brachial orthostatic pulse pressure and systolic BP associated with age and anthropometric variables.
Conclusion: Orthostatic leg BP is independently associated with cardiac structure in normotensive subjects.
- © 2012 by American Heart Association, Inc.