Abstract 15004: Impact of Coronary Artery Calcification on Left Ventricular Diastolic Function in Patients without Previous Coronary Artery Disease

Abstract

Background Coronary artery calcium score (CACS) is a predictor of outcome in patients with subclinical atherosclerosis; however, the influence of coronary artery calcification on cardiac function has not been fully evaluated.

Methods and results 153 subjects without a history of coronary artery disease (CAD) were enrolled in this study.Subjects underwent CACS (coronary artery calcium score) determination by multi detector computed tomography with ECG gating. CACS was calculated using the Agaston criteria. All subjects were classified into four groups according to the severity of CACS: normal (≤10, n=71), mild (11 to 100, n=32), moderate (101 to 400, n=22), severe (401<, n=28). The left ventricular (LV) systolic and diastolic function was evaluated with echocardiography. Prevalence of diabetes mellitus was increased with CACS (11%, 25%, 27%, 50%, p=0.001). There was no difference in LV systolic function among groups; however, diastolic dysfunction assessed byE/e was associated with CACS (8.9+/-3.0, 8.8+/-2.1, 9.9+/-3.1, 11.9+/-5.3, respectively, p=0.002). In univariable analysis, CACS was associated with E/e (r=0.26, p=0.002). In multivariable analysis, the relationship between CACS and E/e was still significant after adjustment for age, gender, incidence of hypertension and diabetes mellitus.

Conclusion Coronary artery calcification was associated with LV diastolic dysfunction even in patients without history of coronary artery disease, which may be involved in the poor prognosis of patients with severe coronary calcification.