Abstract 14884: Low Birth Weight is Independently Associated with Measures of Arterial Stiffness in Healthy Adults
Background: Low birth weight is associated with increased cardiovascular morbidity and mortality, and earlier onset of disease in adulthood; however, the mechanisms underlying the link between birth weight and cardiovascular disease remain unclear. We investigated the relationship between self-reported birth weight and measures of vascular function in healthy adults, with the hypothesis that low birth weight will be associated with increased arterial stiffness in a low-risk population.
Methods: Weight at term birth was reported by 429 subjects (mean age= 47.7, 72.3 % women) recruited as part of Emory’s predictive health cohort. Arterial stiffness was assessed by radial applantation tonometry (SphygmaCor™, Australia), calibrated by brachial blood pressure measurements to derive aortic (central) pressure and wave reflection parameters (Augmented Pressure: AP, Augmentation Index corrected for heart rate of 75 BPM: AIX_75, respectively).
Results: Mean reported weight at term birth was 3.3 ± 0.55 Kg; 8.6 % (37/429) of participants reported low birth weight (< 2.5 Kg). Birth weight was significantly correlated with adult BMI (r=0.17 p<0.001), AIX_75 (r=-0.14 p=0.005), AP (r=-0.12 p=0.014). In age and gender-adjusted regression models, birth weight was independently associated with AIX_75 (β =-0.097, p=0.018) and AP (β =-0.091 p=0.028).
Conclusion: Low birth weight is independently associated with worsened central pressure parameters and increased arterial stiffness in an asymptomatic population with low cardiovascular risk factor burden. Whether incorporating term birth weight classification into cardiovascular risk scores would improve their predictive value needs further investigation.
- © 2012 by American Heart Association, Inc.