Abstract 14868: Quality of Life On or Off Anti-Arrhythmic Drugs in AF Patients Free of Post-Ablation Recurrence
Introduction: Atrial Fibrillation (AF) is commonly associated with considerable impairment in quality of life (QoL). As the treatment of AF largely focuses on controlling symptoms and improving QoL, QoL measurement is considered as a powerful tool in evaluating the outcome of therapy. This study examined QoL in post-ablation AF patients on or off anti-arrhythmic drugs (AAD).
Methods: This prospective study included 150 consecutive AF patients experiencing recurrence after the first ablation. Thirty-three of 150 patients remained on sinus rhythm (SR) with previously ineffective AAD (group 1). Out of the remaining 117 patients that opted for and underwent redo ablation, 90 (group 2) were arrhythmia-free off-AAD at 6-month. Medical Outcome Survey (SF-36) and Beck Depression Inventory (BDI) scales were used to measure QoL at baseline and 6-month of resuming AAD in group 1 and 6-month post-redo in group 2.
Result: In group 2, significant improvement from baseline was noticed in scores for most of the subscales of SF-36, e.g. energy fatigue (60±22 vs. 42±17, p=0.027), physical functioning (81±19 vs. 59±25, p=0.006), emotional well being (77±16 vs. 66±15, p=0.062), limitations due to emotional problem (11% vs. 36%, p <0.001) and social functioning (85±23 vs. 60±25, p=0.010). In group 1, none of the subscale scores of SF-36 demonstrated significant improvement except general health (60±10 vs. 65±12, p=0.03). BDI score showed considerable improvement in the depression status of patients off AAD (on AAD vs off AAD, 6.9±6.5 vs. 4.2±4.3, p= 0.036).
Conclusion: Despite the absence of AF in both groups, post-ablation QoL significantly improves in AF patients off AAD only and not in those on AADs.
- © 2012 by American Heart Association, Inc.