Abstract 14434: Effects of Additional Eicosapentaenoic Acid to Statin Therapy on Inflammatory Cytokines and the Tissue Characterization of Coronary Plaque Assessed by Integrated Backscatter Intravascular Ultrasound Systems
Backgrounds: Recently, assessment of the plaque component has become possible using an integrated backscatter intravascular ultrasound (IB-IVUS). The effect of eicosapentaenoic acid (EPA) has been focused, however, effects of EPA on coronary plaque component and inflammatory cytokines are not known.
Methods: A total of 46 patients, who had been treated with strong statin for at least six months, were randomized to two groups: EPA group (additional treatment with EPA 1800mg/day, n=24) or control group (no additional treatment, n=22) for six months. The tissue characteristics of target coronary plaque in each patient were analyzed using IB-IVUS before and after treatment. We also measured plasma levels of inflammatory cytokines sampled in coronary sinus (CS) and sinus of Valsalva (V). The transcardiac gradient (Δ) was defined as the CS level minus V level.
Results: Significant reduction of lipid volume (44.3±14.7 to 38.2±14.0%, P<0.05) and significant increases of fibrous volume (50.9±12.6 to 56.0±11.3%, P<0.05) were observed on IB image analyses in the EPA group, while there were no significant changes in plaque component in the control group. The Δ interferon-inducible protein of 10kd (IP-10) was smaller after than before treatment with EPA (7.8±11.5 to 0.4±4.0pg/ml,p<0.05), however, there were no significant changes in ΔIP-10 between pre- and post-treatment in the control group.
Conclusions: Decreased local inflammatory response and plaque stabilization were observed after EPA treatment. These findings might be associated with local anti-inflammatory and antiarteriosclerotic effects of EPA.
- © 2012 by American Heart Association, Inc.