Abstract 14376: Circulating GLP-1 is a Superior Biomarker for Monitoring Progression of Abdominal Aortic Aneurysm to Cystatin C
[INTRODUCTION] Glucagon-like peptide 1 (GLP-1) is a incretin hormone that exhibits diverse actions on cardiovascular disease. For instance, GLP-1 reduces atherosclerosis by inhibiting the inflammatory responses in apoE-knockout mice. However, the role of GLP-1 in vascular remodeling related to abdominal aortic aneurysm (AAA) remains unclear. Vascular inflammation and remodeling is the primary determinants of AAA progression. Ample evidence has proposed biomarkers for AAA; i.e., high-sensitive CRP (hsCRP), TIMP-1 MMP9, TGF-β, and cystatin C; however, a consensus for the best surrogate marker remains uncertain.
[HYPOTHESIS] We assessed the hypothesis that GLP-1 may be a novel biomarker for monitoring AAA progression reflecting vascular inflammation. We compared GLP-1 and several biomarkers for AAA to identify the best surrogate in relation to AAA progression.
[METHODS] We enrolled 95 consecutive presurgical Japanese AAA patients (mean AAA diameter 3.6±0.5 cm, %male; 84.2%, mean age; 73.0±9.1 year-old) and AAA-patients were divided into 2 groups according to the median value of AAA-diameter (smaller than 3.7 mm, n = 48, and larger than 3.7 mm, n = 47). Cigarette smoking, statins, age, GLP-1 and biomarkers indicating vascular remodeling (MMP2, MMP9, TIMP1, cystatin C, TGF-β, MDA-LDL, and hsCRP) and renal function (eGFR) were analyzed for the correlation between AAA size.
[RESULTS] In the larger AAA group, GLP-1 and cystatin C concentrations were positively correlated with AAA diameter (R=0.48, P<0.001 for GLP-1 and R=0.2, P=0.029 for cystatin C). The hsCRP exhibited positive correlation with GLP-1 (R=0.38, P=0.002) and cystatin C (R=0.3, P<0.0001) and the value of cystatin C exhibited negative correlation with eGFR value (R=-0.69, P<0.0001) that had no association with GLP-1 value (R=-0.54, P=0.09) exclusively to the larger AAA group. These trends were absent in the smaller AAA group.
[CONCLUSIONS] Present study reports the first and largest database of Asian-ethnic patients with presurgical stage of AAA and demonstrates a pivotal role of GLP-1 as a biomarker for monitoring vascular inflammation occurred in AAA. GLP-1 is superior to cystatin C in terms of imperviousness to the comorbid renal dysfunction.
- © 2012 by American Heart Association, Inc.