Abstract 14286: Vascular Structure and Function in Healthy Obese Subjects
Objectives: Atherosclerotic plaques and increased arterial stiffness are recognized as predictors of cardiovascular events. However, the association between preclinical structural and functional vascular changes has been less studied in healthy overweight subjects.
Methods: Ultrasound of the carotid and femoral arteriesand applanation tonometrywere performed in 126 subjects (age 51±10 years, 60% women and body mass index [BMI] 32.5±4.8 kg/m2) included in the FAT-associated CardiOvasculaR (FATCOR) project. Plaque was defined as an intima-media thickness (IMT) ≥1.50 mm. Vascular function was assessed by carotid femoral pulse wave velocity (PWV) and central blood pressure.
Results: In the total study population, mean IMT was 0.71±0.02 mm and plaques were detected in 33%. Subjects with plaques were older (57±9 vs. 48±9 years), included more smokers (26% vs. 15%) and had higher central systolic blood pressure (127±19 vs.117±16 mmHg, all p<0.05) while prevalence of hypertension and diabetes did not differ. Smoking (β=0.20), higher age (β=0.38) and PWV (β=0.28) were independent predictors of increased IMT in multiple linear regression analysis (Multiple R2= 0.34, all p<0.01). In multiple logistic regression analysis, age and smoking were the independent predictors of presence of atherosclerotic plaques (table).
Conclusions: Higher IMT is associated with increased arterial stiffness in obesity. However, in healthy overweight subjects subclinical atherosclerotic plaques were primarily predicted by smoking. Table: Predictors of atherosclerotic plaques
- © 2012 by American Heart Association, Inc.