Abstract 14003: Low-Intensity Pulsed Ultrasound Improves Endothelial Function in Leg Circulation in Patients with Peripheral Arterial Disease
Background: Low-intensity pulsed ultrasound (LIPUS) induces osteogenesis and angiogenesis. The purpose of this study was to evaluate the effect of LIPUS on clinical symptoms and endothelial function in patients with peripheral arterial disease (PAD). Methods and Results: We assessed clinical symptoms and flow-mediated vasodilation (FMD) in leg circulation during a 24-week period of LIPUS irradiation in 25 patients with PAD, including 12 patients with Buerger disease and 13 patients with atherosclerotic PAD. Twenty-five patients who did not receive LIPUS irradiation served as controls. This was a double-blinded, randomized, active and inactive LIPUS study. Treatment with LIPUS for 24 weeks improved popliteal artery FMD from 7.3±1.8% to 10.2±2.9% in Buerger disease patients and from 5.8±1.7% to 9.3±3.2% in atherosclerotic PAD patients (P=0.01 and P=0.03, respectively). Nitroglycerine-induced vasodilation was similar in any treatment periods in all of the groups. LIPUS increased the number of and migration of circulating progenitor cells (Buerger disease: 1158±420 to 1716±512/mL (P=0.01), 79±34 to 121±51/hpf (P=0.02); atherosclerotic PAD:612±280 to 1018±476/mL (P=0.01), 43±19 to 71±39/hpf (P=0.01)). There were significant relationships between the number of and migration of circulating progenitor cells and FMD (r=0.48 and r=0.33, P=0.0001 and P=0.02, respectively) in all patients. In both Buerger disease and atherosclerotic PAD patients, visual analog pain score was significantly decreased after 24-week LIPUS treatment. No severe adverse effects were observed in any of the patients who underwent LIPUS treatment.
- © 2012 by American Heart Association, Inc.