Abstract 13953: High-Sensitivity Troponin I Values Depend on Patient's Age and Gender
Purpose: High sensitivity Troponin (hsTn) assays are increasingly being introduced for routine purposes. We evaluated a hsTnI assay in an apparently healthly, working population to assess assay characteristics and marker distribution. Hypothesis: TnI values assessed with a high sensitivity assay differ between men and women and in different age groups.
Methods: 300 apparently healthy staff members (150 men and 150 women, 50% below and above 40 years of age, respectively) of the University Hospital Charité Berlin were recruited. Subjects with a medical history of cardiac, renal or metabolic diseases were excluded. HsTnI was analyzed from frozen samples using the prototype ARCHITECT STAT hsTnI assay.
Results: The overall CV (coefficient of variation) of the assay at 20 pg/ml (99th percentile value 23.72 pg/mL) was 3.96 %. Median age in our cohort was 39 (25th/75th %ile 33/46) years. Median hsTnI value for all subjects was 0.55 (0.0/1.45) pg/ml in EDTA plasma with a 99th%ile cut-off at 23.72 pg/mL. hsTnI values were significantly associated with age and gender (p=0.001 and p<0.0001 respectively) with lower values in female and younger subjects, although the 99th %ile was higher in women (Table).
Conclusion: The prototype ARCHITECT STAT hsTnI assay meets the requirements of the Universal Definition of Acute Myocardial Infarction. Overall, values were lower in serum samples than in EDTA and lithium heparin plasma samples. hsTnI values were significantly gender and age dependent which adds to the complexity of interpreting results in a clinical setting.
- © 2012 by American Heart Association, Inc.