Abstract 13878: The Influence of Alcohol Use on Vascular Complications and Mortality in Patients with Type 2 Diabetes Mellitus

Abstract

Background: Moderate alcohol consumption is associated with a reduced risk of mortality and adverse cardiovascular events in general populations. We studied whether alcohol use is associated with major macro- and microvascular events and all-cause mortality in patients with type 2 diabetics in the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron modified release Controlled Evaluation) trial. Research Design and

Methods: The effect of weekly alcohol use at baseline was examined in multivariable logistic regression models adjusted for potential confounders. The study end-points were macrovascular (cardiovascular death, myocardial infarction or stroke) and microvascular (new or worsening nephropathy or retinopathy) events and all-cause mortality.

Results: A total of 11,140 patients were included in the current analyses, of whom 30% reported regular weekly alcohol consumption of at least one standard drink weekly. During a median of 5 years of follow up, 1,031 (9%) patients died, 1,147 (10%) experienced a major macrovascular event and 1,136 (10%) a major microvascular event. Compared to patients who drank no alcohol, those who consumed alcohol regularly were at a decreased risk of macrovascular events (adjusted HR 0.84, 95% CI 0.73-0.97, p=0.018), microvascular complications (adjusted HR 0.85, 96% CI 0.73-0.99, p=0.032) and all-cause mortality (adjusted HR 0.86, 95% CI 0.74-0.99, p=0.038). Compared to those who drank other types of alcohol, patients who drank only wine exhibited a non-significant trend towards lower mortality (unadjusted HR 0.77, p=0.06; HR adjusted for age, sex, study group and education 0.79, p=0.10).

Conclusions: Alcohol use is associated with a reduction incidence of major macrovascular and microvascular events and all-cause mortality in patients with type 2 diabetes.