Abstract 13812: The Influence of Exercise on Vascular Complications and Mortality Ii Patients with Type 2 Diabetes Mellitus
Background: It is generally presumed that patients with diabetes who participate in regular exercise will experience fewer vascular complications. The evidence for this is, however, limited. In particular, the effects of exercise on microvascular events are unclear. We studied the association between self-reported weekly exercise and macro- and microvascular events in patients with type 2 diabetics in the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron modified release Controlled Evaluation) trial. Research Design and
Methods: The effect of weekly exercise (for at least 15 minutes), categorized as none, mild, moderate or vigorous, was examined in multivariable logistic regression models adjusted for potential confounders. The study end-points were macrovascular (cardiovascular death, myocardial infarction or stroke) and microvascular (new or worsening nephropathy or retinopathy) events and all-cause mortality.
Results: A total of 11,140 patients were included in the analyses, of whom 46% reported moderate to vigorous exercise for ≥15 minutes per week. During a median of 5 years of follow up, 1,031 (9%) patients died, 1,147 (10%) experienced a major macrovascular event and 1,136 (10%) a major microvascular event. Compared to patients who took no or only mild exercise, those participating in moderate to vigorous activity had a decreased risk of macrovascular events (adjusted HR 0.77, 95% CI 0.68-0.78, p<0.001) microvascular events (adjusted HR 0.85, 95% CI 0.75-0.96, p=0.007) and all-cause mortality (adjusted HR 0.82, 95% CI 0.72-0.93, p=0.003).
Conclusions: Participation in moderate to vigorous exercise for ≥15 minutes per week is associated with a reduction of macrovascular and microvascular complications and all-cause mortality in patients with type 2 diabetes.
- © 2012 by American Heart Association, Inc.