Abstract 13733: Circulating Matrix Metalloproteinase Levels Correlate with Severity in Marfan Syndrome
Tissue matrix metalloproteinases (MMPs) participate in extra-cellular matrix destruction in aneurysm disease, with MMP2, MMP3 and MMP9 being elevated in atherosclerotic thoracic aneurysm. MMP2 and MMP9 have been shown to be elevated in Marfan aortic tissue, but no data are available on levels of MMPs in peripheral blood. Peripheral venous blood levels of MMP2, MMP3 and MMP9 were measured in duplicate (Luminex) in 15 unrelated controls, 47 Marfan (Ghent criteria) patients and 13 patients with isolated familial aneurysm (FTAD). Variation in repeat MMP measurements was less than 10%. Aortic geometry was measured by echocardiography. Plasma MMP2 levels were increased in Marfan and familial aneurysm patients. In contrast, plasma MMP3 levels were reduced in Marfan and familial aneurysm patients. In patients with severe aortic dilatation (maximum diameter > 45 mm) plasma MMP2 (518 + 159 ng/ml) was greater than in those with milder aortic dilatation (405 + 112 ng/ml, p=0.02). Plasma MMP2 and MMP3 levels are significantly altered in heritable aortopathy and appear to correlate with severity of aortic disease. Plasma MMP9 was not altered in MFS and plasma MMP3 was decreased, which contrasts with the substantial increase in MMP9 and the moderate increase in MMP3 seen in atherosclerotic thoracic and abdominal aneurysm. Plasma MMP2 and MMP3 levels have the potential to assist in diagnosis, improve stratification for risk of aneurysm progression and may be suitable to monitor response to pharmacological intervention.
- © 2012 by American Heart Association, Inc.