Abstract 13459: Intima-media Thickness of Brachial Artery and Endothelial Function
Background: Cardiovascular diseases are associated with impaired flow-mediated vasodilation (FMD) and increase in carotid intima-media thickness (IMT). Both FMD and IMT are independent predictors for cardiovascular outcomes. When measuring FMD in the brachial artery, IMT can also be simultaneously assessed in the same brachial artery. Although the impact of endothelial function on structural arterial change has been investigated in several studies, different vascular beds, the brachial artery for FMD and common carotid artery for IMT, were examined in these studies. The purpose of this study was to determine the direct interrelation between FMD as an index of endothelial function and IMT of the brachial artery.
Methods and Results: We measured brachial IMT and FMD by ultrasound in 388 subjects who underwent health examination (mean age, 45±22 years; age range, 19 to 86), including patients with cardiovascular diseases. The mean value of brachial IMT was 0.29±0.10 mm and that of FMD was 5.1±3.5%. There was no significant difference in brachial IMT and FMD between men and women (0.29±0.10 vs. 0.27±0.08 mm and 5.1±3.4% vs. 5.1±3.7%, P=0.11 and P=0.87, respectively). FMD was inversely associated with brachial IMT (r=-0.39, P<0.001). Significant relationships between brachial IMT and FMD were found in both men (r=-0.41, P<0.001) and women (r=-0.36, P<0.001). In addition, there was a significant relationship between brachial IMT and carotid IMT, as established surrogate marker of atherosclerosis (r=0.58, P<0.001).
Conclusion: These findings suggest that there is a direct interaction between endothelial function and IMT and that brachial IMT may be a marker of endothelial function, providing additive information for stratifying subjects with cardiovascular risk factors.
- © 2012 by American Heart Association, Inc.