Abstract 13353: Gender Differences on the Relationship Between Long Term Fish Intake and Kidney Function in Elderly Individuals, in Respect to Overall Dietary Pattern: The Ikaria Study

Abstract

Objectives: The aim of this work was to evaluate the correlation between amount of weekly fish intake and kidney function as measured by creatinine-clearence (CCr) rate, among elderly inhabitants of Ikaria Island; a place with increased rates of longevity. Materials/

Methods: 328 (75±7 years) men and 339 (75±6 years) women long term residents were enrolled. Nutritional habits, including fish intake, were evaluated using a validated, semi-frequent food questionnaire and the MedDietScore. Urea and creatinine were measured and CCr rate was estimated by the Cockcroft-Gault formula.

Results: 84% participants reported >150 g/week fish consumption; 35% had moderate to severe CCr (<60 ml). Elders in the highest tertile of fish consumption (i.e., >43 g/day) were slightly older (74±6 yr vs. 72±6 yr, p=0.001), more likely being men (63% vs. 43%, p=0.001) and obese (36% vs. 25%, p=0.03) and showed closer adherence to the Mediterranean diet (MedDietScore: 39±3 vs. 37±2, p=0.001), as compared with those in the lowest tertile of fish consumption (i.e., <32 g/day).Crude analysis revealed that CCr rate was positively associated with fish intake (b±SE per 100 g/day: 24±9, p=0.007); multiple linear regression analysis confirmed the previous finding (b±SE per 100 g/day: 11±2, p=0.001), after adjusting for other potential confounders. Furthermore, multi-adjusted logistic regression analysis showed that fish consumption of 100 g/day increased the likelihood by 121% of having CCr >60 ml (95%CI 10%-343%). Then, the analysis was stratified into elders who were < or >38 of the MedDietScore (mean score of the sample).Fish consumption was associated with higher CCr rate among women who were below the average MedDietScore (b±SE per 100 g: men, 5.4±4.7, p=0.25, women, 15.8±6.8, p=0.02), as well as among women who were above the average diet score (b±SE per 100 g: men, 1.7±.8, p=0.80, women, 35.3±8.8, p=0.002), after adjusting for the same covariates’ pattern.

Conclusions: Long term fish consumption was independently associated with kidney function among elderly individuals, but shows gender differences in relation to overall dietary pattern ; a finding that extends the current knowledge regarding the benefits of fish intake on human health.