Abstract 13195: Intermittent Neural Transmission Block of the Intra-Abdominal Vagus Induces Sustained Blood Pressure Reduction in Obese Subjects
BACKGROUND: Intermittent block of the intra-abdominal vagus (VBLOC) using an implantable device (Maestro RF System) has been shown to cause significant excess weight loss (EWL) in obese subjects. We tested the hypothesis that VBLOC would improve blood pressure (BP) prior to significant WL in obese subjects with a diagnosis of hypertension (HT) or elevated BP at baseline. METHODS: BP was measured at baseline, weekly to 4 wk and monthly to 12 mo during a randomized, controlled trial to evaluate weight loss in 294 obese subjects. HT was defined by JNC-7 guidelines (group A) or if subjects had HT history (group B); the analysis was performed in a subset of subjects who had ≥9 hrs therapy delivered per day to 12 mo. RESULTS: Demographics for groups A (n=37) and B (n=58) were BMI 41±1 and 41±1, age 50±1 and 51±1, and female/male 31/6 and 47/11, respectively (mean ± SE). EWL reductions were 9±1 and 9±1, 12±1 and 13±2, 21±4 and 23±3% at 2, 4 wk and 12 mo for groups A and B, respectively (P<.001 from baseline). Systolic BP reductions were 17±3 and 10±2, 17±3 and 9±2, 18±3 and 13±2 mmHg at 2, 4 wk and 12 mo (P<.001) from baseline; 145±2 and 134±2 mmHg in groups A and B, respectively. Diastolic BP reductions were 9±2 and 6±1, 8±2 and 6±1, and10±2 and 7±1 mmHg at 2, 4 wk and 12 mo (P<.001) from baseline; 89±2 and 84±1 mmHg in groups A and B, respectively. BP reduction was not dependent on weight loss magnitude (P=NS). Baseline BP and reduction in BP were positively correlated (P<.001). CONCLUSIONS: VBLOC induced clinically significant, sustained BP reduction at 1 year in obese subjects with a history of HT or elevated BP prior to therapy. These data suggest that VBLOC therapy may offer major non-pharmacologic BP reduction for obese subjects with HT.
- © 2012 by American Heart Association, Inc.