Abstract 13120: Monocyte Chemoattractant Protein-1 and Interleukin-6 Predict Post-Operative Clinical Outcome in Patients Undergoing Elective Coronary Artery Bypass Grafting Operation
Background: Low-grade inflammation is strongly involved in the pathophysiology of coronary artery disease. However, the role of background (preoperative) low-grade inflammation on clinical outcome post-coronary artery bypass grafting (CABG) operation is unclear. We explored the role of key components of low-grade inflammation such as interleukin-6 (IL-6), C-reactive protein (hsCRP) and monocyte chemoattractant protein-1 (MCP-1) in the clinical outcome of patients undergoing elective CABG.
Methods: We recruited 181 patients scheduled for elective CABG. The morning before the operation, following an 8-hour fasting period, blood samples were obtained and MCP-1, IL-6 and hsCRP levels were determined by ELISA. The patients were then followed-up until their discharge from the hospital.
Results: Higher MCP-1 (A) and IL-6 (B) but not hsCRP (C) levels were associated with increased length of hospital stay for those patients. In cox-regression, MCP-1 and IL-6 (as continuous variables) were predictors of the length of hospital stay (P<0.01), independently of risk factors, Euroscore, extent of coronary artery disease and left ventricular ejection fraction preoperatively.
Conclusions: Lower pre-operative MCP-1 and IL-6 levels are associated with decreased length of in-hospital stay following CABG, whereas CRP levels (the most commonly used inflammatory biomarker) failed to predict the length of hospitalization in these patients. These findings suggest that combined evaluation of MCP-1 and IL-6 provides a good description of background immunological activation relevant to the pathophysiology of post-operative complications in patients undergoing CABG. These findings may have direct clinical implications in risk prediction post cardiac surgery.
- © 2012 by American Heart Association, Inc.