Abstract 13083: Prediction of Non-Sustained Ventricular Tachycardia by 99mTc- Tetrofosmin Myocardial Perfusion Imaging in Patients with Coronary Artery Lesions Caused by Kawasaki Disease
Background: Ventricular tachycardia (VT) can occur in some patients with coronary artery lesions (CAL) caused by Kawasaki Disease (KD), and it affects the outcome. The aim of this study is to know the risk factor for the appearance of non-sustained VT (NSVT) in the late period after KD by 99mTc-tetrofosmin myocardial perfusion imaging (MPI).
Methods: We retrospectively analyzed the relation between the appearance of NSVT and the findings in MPI single-photon- emission computed tomography (SPECT) at rest in 92 pts (66 males and 26 females) who had had CAL caused by KD. All 92 pts had undergone MPI at rest and 24-h Holter electrocardiogram (h-ECG) at the same time between 2003 and March 2012. The extent score, which indicates myocardial perfusion defect, and the left ventricular ejection fraction (LVEF) were calculated by Quantitative Perfusion SPECT software, and Quantitative Gated SPECT software, respectively. We analyzed which factors influenced the appearance of NSVT by univariate and multivariate logistic regression models. Furthermore, we calculated the cut-off point for the appearance of NSVT after KD using receiver operating characteristic curve.
Results: The interval from the onset of KD to MPI ranged from 1 month to 47 years, and the median was 17 years. NSVT was detected in 15 pts (16%) in h-ECG. The factors influenced the appearance of NSVT by univariate logistic regression model were LVEF (p<0.0001), Extent (p<0.0001), and the interval from the onset of KD to MPI (p=0.0006). The cut-off points were as follows, LVEF 0.56 (AUC 0.82), Extent, 12 (AUC 0.93), the interval from KD to MPI, 17 years (AUC 0.68). In multivariate logistic regression model, the significant risk factor was Extent (p<0.0001).
Conclusion:The most important factor for NSVT in patients with CAL caused by KD was “Extent “obtained by MPI, and its cut-off point was 12.
- © 2012 by American Heart Association, Inc.