Abstract 13001: Intima-media Thickness of Brachial Artery and Cardiovascular Risk Factors
Objectives: Measurement of intima-media thickness (IMT) in the artery is established as an index of structural change of the artery. IMT is one of the manifestations of atherosclerosis and usually assessed in the carotid artery. Several lines of evidence suggest that carotid IMT is associated with cardiovascular risk factors and is a predictor of cardiovascular outcomes. However, there is little information on whether IMT of the brachial artery can serve as a surrogate maker for progression of atherosclerosis. The purpose of this study was to determine the relationship between IMT of brachial artery and cardiovascular risk factors.
Methods and Results: We measured brachial IMT by ultrasound in 388 subjects who underwent health examination (mean age, 45±22 years; age range, 19 to 86), including patients with cardiovascular diseases. The mean value of brachial IMT was 0.29±0.10 mm. Univariate regression analysis revealed that brachial IMT significantly correlated with age (r=0.71, P<0.001), body mass index (r=0.27, P<0.001), systolic blood pressure (r=0.40, P<0.001), diastolic blood pressure (r=0.31, P<0.001), heart rate (r=0.15, P=0.002), glucose level (r=0.18, P=0.01), and smoking pack year (r=0.42, P<0.001) as well as Framingham risk score, a cumulative cardiovascular risk index for heart attack (r=0.49, P<0.001). We classified subjects into 3 groups based on Framingham risk scores: low group, intermediate group, and high group. Brachial IMT increased in relation to increase in the Framingham risk score (low group, 0.27±0.06; intermediate group, 0.33±0,10; high group, 0.37±0.08 mm; P<0.001, respectively). Subjects were categorized into 3 tertiles based on brachial IMT. There were significant increases in the prevalence of hypertension, dyslipidemia, diabetes mellitus, smoking, coronary heart disease, and cerebrovascular disease with increase in brachial IMT. Multivariate analysis revealed that age, sex, hypertension and brachial artery diameter were independent predictors of brachial IMT.
Conclusion: These findings suggest that brachial IMT may be a marker of the grade of atherosclerosis and may be used as a marker of cardiovascular disease, providing additive information for stratifying subjects with cardiovascular risk factors.
- © 2012 by American Heart Association, Inc.