Abstract 12916: Elevation of Fatty Acid-Binding Protein 4 is Predisposed by Family History of Hypertension and Contributes to Blood Pressure Elevation
[Background] Fatty acid-binding protein 4 (FABP4/A-FABP/aP2), a lipid chaperone, is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, and atherosclerosis. However, little is known about the role of FABP4 in essential hypertension. [Methods] First, using blood samples in 296 subjects on no medication of our cohort, the Tanno-Sobetsu study cohort, correlation between serum FABP4 level and blood pressure was examined. Second, we next examined difference between serum FABP4 concentrations in 18 normotensives (NT) and 30 non-treated essential hypertensives (EHT). The EHT were divided into 18 insulin-sensitive EHT (EHT-S) and 12 insulin-resistant EHT (EHT-R) based on their insulin sensitivity index, the M value, determined by the hyperinsulinemic-euglycemic clamp technique. We lastly determined FABP4 levels in 30 young normotensive men with or without a family history of hypertension (FH+ and FH-, respectively; n = 15 each). [Results] In the cohort subjects, serum FABP4 level was positively correlated with blood pressure (r = 0.26, P < 0.001), and blood pressure was an independent determinant of FABP4 concentration after adjustment of age and gender. Serum FABP4 level was significantly higher in the EHT-R than in the NT (24.2 ± 2.0 vs. 15.3 ± 1.5, P = 0.003), whereas elevation of FABP4 level in the EHT-S was not statistically significant. FABP4 level was positively correlated with age, body mass index, blood pressure, and triglycerides and negatively correlated with the M value. FABP4 level was an independent predictor of mean arterial pressure after adjustment of age, gender, and adiposity. The FH+ group had a significantly lower level of M value and higher level of FABP4 than did the FH- group, and FABP4 concentration was an independent determinant of the M value. [Conclusions] FABP4 contributes to blood pressure elevation and atherogenic metabolic phenotype in hypertensives, and the elevation of FABP4 level is predisposed by a family history of hypertension.
- © 2012 by American Heart Association, Inc.