Abstract 12905: Chronic Effect of Cibenzoline on Left Ventricular Pressure Gradient, Left Ventricular Diastolic Function and Left Ventricular Hypertrophy in Patients with Hypertrophic Obstructive Cardiomyopathy
Aim: We examined the chronic effect of antiarrhythmic drug, cibenzoline on left ventricular pressure gradient (LVPG), left ventricular diastolic function and left ventricular hypertrophy in patients with hypertrophic obstructive cardiomyopathy (HOCM).
Methods: Forty-eight patients with HOCM participated (mean age:58±12 years). Mean dose of cibenzoline was 293±40mg/day, and mean follow-up period was 56.0±28.4 months. In addition to cibenzoline, β-blocker was administered to 40 patients and Ca-antagonist was administered to 29 patients. Before administration of cibenzoline and at the chronic stage of the treatment, LVPG and E-velocity/A-velocity ratio (E/A ratio) was measured in echocardiogram, and in electrocardiogram heart rate (HR), SV1+RV5, depth in negative T wave and HR corrected QT interval (QTc) were measured.
Results: [[Unable to Display Character: ①]]HR decreased from 74±14/min to 63±9/min. [[Unable to Display Character: ②]]LVPG decreased from 93.8±49.9 mmHg to 19.0±18.8 mmHg.[[Unable to Display Character: ③]]E/A ratio increased from 0.75±0.42 to 1.52±0.62. [[Unable to Display Character: ④]] SV1+RV5 decreased from 49.8±19.3 mm to 35.3±15.7 mm. [[Unable to Display Character: ⑤]] depth in negative T wave decreased from 8.0±7.3 mm to 5.1±5.7 mm. Negative T wave in 7 patients with HOCM changed to positive. [[Unable to Display Character: ⑥]] QTc shortened from 0.486±0.051 msec to 0.455±0.050 msec. These changes were all significant.
Conclusion: These results indicate that the treatment with cibenzoline can decrease LVPG, improve left ventricular diastolic dysfunction and bring about left ventricular regression to patients with HOCM without any serious side effects.
- © 2012 by American Heart Association, Inc.