Abstract 12872: In vivo Comparison of Fourier-Domain Optical Coherence Tomography and Intravascular Ultrasonography (OPUS -CLASS Study)
Aim: Although frequency domain OCT (FD-OCT) has been introduced recently in clinical practice, efficacy and feasibility of it has not been described yet in vivo in human. Thus, the aim of this study was to compare the reliability and feasibility of FD-OCT to intravascular ultrasound (IVUS) in coronary lesion assessment.
Methods: FD-OCT and IVUS were performed prospectively in 5 centers in 100 patients with coronary artery disease (CAD) at the time of coronary angiography (CAG) (20 cases) before and after stenting (60 cases) and at stent follow-up (20 cases). Quantitative analyses were performed in minimum lumen diameter and area (MLD and MLA, respectively) in FD-OCT, IVUS and quantitative CAG (QCA) in addition to qualitative morphological assessment.
Results: Compared with QCA, MLD was significantly greater in OCT and IVUS (1.85 ± 0.77 vs. 1.94 ± 0.70 vs. 2.10 ± 0.59 mm, p < 0.001, respectively), and it was significantly greater in IVUS compared with OCT (p<0.001), although there were significant correlations one another (IVUS vs. OCT, QCA vs. OCT and QCA vs. IVUS; R2= 0.92, 0.83 and 0.82, p < 0.001 respectively). MLA was also significantly greater in IVUS compared with OCT (3.70 ± 2.04 vs. 3.36 ± 2.28 mm2, p < 0.001), although a significant correlation was observed between them (y = 0.85x + 0.83, p < 0.001). Furthermore, OCT was superior to IVUS in inter-observer variability in MLA (y = 1.01x - 0.01, R2= 0.995, p < 0.001 vs. y =1.04x - 0.11, R2= 0.97, p < 0.001), and it was much more sensitive in detecting tissue prolapsed (100 vs. 14 %, p < 0.01), thrombus (7 vs. 0 %, p < 0.01), dissection, mal-apposition qualitatively compared with IVUS.
Conclusions: This prospective multicenter study demonstrates that much more precise evaluation can be expected in coronary lesion by OCT compared with IVUS even in vivo in human. FD-OCT should be more reliable and feasible in the assessment of coronary lesion morphology more than IVUS qualitatively and quantitatively in the clinical setting.
- © 2012 by American Heart Association, Inc.