Abstract 12833: Specific Organized Substrates of Ventricular Fibrillation: Comparison of 320 slice CT Heart Images in Non-Ischemic Ventricular Fibrillation Subjects with Non-Ischemic Sustained and Non Sustained Ventricular Tachycardia Subjects
Purpose: If specific organized substrates of ventricular fibrillation (VF) are identified, they may provide important information for prevention of sudden cardiac death. To identify specific organized substrates of VF, we compared 320 slice CT heart images in non-ischemic VF subjects with non-ischemic sustained and non sustained ventricular tachycardia (VT) subjects.
Materials and Methods: A total of 103 subjects who had VF (17 subjects; age, 59±16 yrs), sustained VT (20 subjects; 62±19 yrs), or non sustained VT (66 subjects; 60±15 yrs) underwent 320 slice CT (Aquilion one).
Results: After excluding 26 ischemic subjects with >50% stenosis in any coronary arteries on CT, myocardial infarction, or coronary vasospastic angina, a total of 77 non-ischemic subjects (12 VF subjects; age, 58±18 yrs), (13 sustained VT subjects; 55±20 yrs) or (52 non sustained VT subjects; 58±15 yrs) were analyzed. On CT, myocardial fibrosis was significantly more frequent in the VF group (75%, all myocardial fibroses in left ventricle) than in the sustained VT group (31%) and the non sustained VT group (35%) (both P<0.01). Myocardial fatty change was significantly more frequent in the sustained VT group (54%) than in the VF group (17%) and the non sustained VT group (12%) (both P<0.01). Final diagnoses of the non ischemic VF and sustained groups included four subjects in each case with normal cardiac structure on transthoracic echocardiogram; the former included two subjects who had fibrosis on CT without specific ECG finding.
Conclusions: Myocardial fibrosis and fatty change on CT may be substrates of VF or sustained VT in non-ischemic subjects. 320 slice CT can evaluate both coronary arteries and myocardium.
- © 2012 by American Heart Association, Inc.