Abstract 12805: Calcific Aortic Stenosis and Marfanoid Habitus
Calcific aortic stenosis (CAS) stands on top among the acquired heart diseases nowadays. Of all the known risk factors for CAS there is no evidence of correlation with the inherited connective tissue disorders. Purpose: to study the prevalence of sigh of systemic involvement and marfanoid habitus (MH) among patients with CAS. Materials and
Methods: Rating the systemic involvement signs and diagnostics were performed according to the Ghent criteria of 2010, and echocardiography of 86 patients of mature and elderly age with CAS were made (men - 54, women - 32, the mean age was 63,8 ± 9 years). Fifty five of 86 patients have already undergone aortic valve replacement. The control group included 61 persons (the mean age 61.3 ± 7.6 years) without clinical, physical or echocardiographic signs of CAS.
Results and Discussion: in patients with CAS we found significantly higher incidence of the skeletal signs such as asthenic thorax (50.0% vs. 23.0%, p <0.05), funnel-shaped deformation of the chest (39.1% vs. 9.8%, p <0.05), arc-like palate (45.3% vs. 22.9%, p <0.05), scoliosis (85.9% vs.31.1%, p 0.05). The MH was seen in patients with CAS four times more often than in control group (26,4% vs. 6,5%, p <0.001). Patients with the biggest number of skeletal signs had significantly higher values of transaortic gradient than patients from the group with a minimal number of skeletal signs (73,7 ± 43,7 mmHg vs. 50,5 ± 34,2 mmHg, p <0.01).
Conclusion: A close cause-effect relationship between skeletal signs, marfanoid habitus and calcific stenosis of aorta. Marfanoid habitus may be considered as a risk factor of development of calcific aortic stenosis.
- © 2012 by American Heart Association, Inc.