Abstract 12767: Delayed Enhancement on Cardiac Magnetic Resonance Imaging is a Poor Prognostic Factor in Patients with Cardiac Sarcoidosis
Background: Although the long-term prognosis of patients with sarcoidosis is generally well, that of patients with cardiac sarcoidosis (CS) is poor as it causes fatal arrhythmias and heart failure. In this study, we thus aimed to identify the predictors of ventricular arrhythmias (VA) and poor outcome in patients with CS.
Methods and Results: We enrolled 61 consecutive CS patients who were admitted to our hospital from April 2002 until March 2012 with a mean follow-up period of 45±31 months. In those CS patients, we examined the relationship between delayed enhancement on cardiac magnetic resonance imaging (DE-MRI) and VA or a composite endpoint, including VA, heart failure hospitalization and cardiovascular mortality. Although there was no significant difference in the baseline clinical characteristics between the patients with VA and those without it, the former group was characterized as compared with the latter by lower left ventricular (LV) ejection fraction (LVEF) (P<0.05), larger LV systolic/diastolic dimensions (both P<0.05) and a significant association with DE-MRI (P<0.05). Furthermore, the patients with DE-MRI (n=26), as compared with those without it (n=11), had a significantly higher composite endpoint event rate (41 vs. 0%, P<0.05) and a trend toward higher prevalence of VA (29 vs. 0%, P=0.12). Univariate analysis also showed that impaired LV systolic function was significantly associated with composite events on follow-up.
Conclusions:These results indicate that the presence of DE-MRI is a significant predictor of VA events and poor outcome in CS patients, suggesting that it could be a useful marker in the management of the disorder.
- © 2012 by American Heart Association, Inc.